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PR#PriorityPesticide(MFG)Commodity (Crop Group)Project Status
13741 A MEFENTRIFLUCONAZOLE ( BASF ) BROCCOLI ( 05-16 = BRASSICA HEAD AND STEM VEGETABLE GROUP ) COMPLETE WITH ON-GOING TRIALS

Reduced Risk Status:
IPM Compatibility: Per Req: Very Good Fit; Some fungal pathogens have figured out how to “sneak” past other DMI’s (triazoles) by altering the shape of their binding pockets. Conventional DMIs are rigid and cannot bind as easily to the altered shape of these binding pockets. They fail to control the disease effectively. This shows up in the field as fungicide resistance. Cevya Fungicide from BASF molecular flexibility can overcome these changes in binding pockets, providing strong performance even on some fungicide-resistant or shifted strains. If you have a molecule, like Cevya (mefentrufluconazole) fungicide that has this capability, you can use lower concentrations (i.e. lower EC50 values, higher intrinsic activity) If you have a molecule that has a poorer fit, you need to overload the system to have the same impact. This new fungicide from BASF appears to provide a long residual efficacy, excellent perf & a favorable environmental profile to give growers the flexibility they need to combat the pathogen resistance:08/23
Reasons for need: Alternaria leaf spot (ALS); The disease is of growing concern to growers nationwide particularly in the Southwestern US/Coastal CA because of decreasing efficacy of narrow number of chemical fungicides available to control the disease. Furthermore due to the limited available chemistries the risk of pathogen resistance to the limited modes of action is considerably large. The goal of this study shall be to generate efficacy and phytotoxicity data to support the registration of Cevya (mefentrifluconazole) to control ALS:08/23; VA/Disease is of high concern for Southeastern growers. Limited availability of chemistries for resistance management:09/23
Requesting State(s): AZ:Hu, J* ; OR:Ocamb, C ; VA:Higgins, D ;
PCR Use Pattern: Apply Cevya at 5 fl oz/A as a foliar spray 3 times every 7 days, PHI = 0 days.
EPA Default Residue Trials: 6 10-6 12
IR-4 Residue Trial Plan: 6 10-4 12 (decline); NAFTA, 5-2, 10-6
Residue Protocol Use Pattern: USE THE CEVYA FUNGICIDE PRODUCT (3.34 LB AI/GAL OF ACTIVE INGREDIENT MEFENTRIFLUCONAZOLE); MAKE 3 FOLIAR APPLIC OF 0.1338 LB AI/A, IN 10-50 GPA, 7-DAY INTERVALS, WITH THE LAST APPLIC ON THE DAY OF THE FIRST OF MULTIPLE HARVESTS (MULTIPLE HARVEST DATES ARE REQUIRED IN EACH TRIAL); ALL APPLIC SHALL INCLUDE A LABELED RATE OF AN ADJUVANT
Efficacy/Crop Safety (E/CS) Data Required: MFG requires both E and CS data from at least 3-4 trials in California to generate the required data to secure registration with CA-DPR
E/CS Research Comments: PER THE 2024 PERFORMANCE PROTOCOL: TESTING FOLIAR APPLIC OF CEVYA AT 2 RATES (88.72 AND 148 ML PRODUCT/A, 3 APPLIC AT 7-DAY INTERVALS), COMPARED WITH A COMMERCIAL STANDARD, FOR CONTROL OF ALTERNARIA LEAF SPOT ON BROCCOLI; EVALUATE DISEASE INCIDENCE AND SEVERITY (INCLUDING HEAD ROT IF POSSIBLE), CROP INJURY AND CROP YIELD
Label Use Pattern Submitted To EPA:
EPA PIF Status: Green 12/23
EPA Status:
EPA PRIA Date:
MRID:
Comments: Requester is looking for CA registration:08/23; Mfg supports as "Researchable, Residue and E/CS data needed" & mfg suggests adding additional decline sampling points for the RAC in the MOR trials to evaluate residue data from multiple PHI and offers to conduct the analytical phase of the residue program.:08/23/sb; EPA Green, 12/23; Residue signed 12/23. perf. not signed: 12/23 JPB; perf protocol signed, status changed from "complete w ongoing trials" to "Residue ongoing e/cs ongoing" 02/24/drs;
International Status:
Archive Location:
QA Archive:

               View International Status                View protocol            PST(Priority Setting Comments)  

Field Research DirectorExpediteTrial DelayField ID#RFCTO QAHQ RECD.Lab ID#Lab RECDLab CompProc. IDProc. ShippedProc. ReportRaw DataS Dir./Auditor
Ennes, D. (Kearney) 24-CA69 24-BAR01 MARCONI HQ
Leach, Nathan 24-CA70 04/10/24 04/16/24 24-BAR01 03/25/24 MARCONI HQ
Benzen, Ms. Sharon D. 24-CA*71 24-BAR01 MARCONI HQ
Benzen, Ms. Sharon D. 24-CA*72 24-BAR01 MARCONI HQ
Skiles, Keri 24-CA73 24-BAR01 MARCONI HQ
Robbins, Chanz 24-NM216 24-BAR01 MARCONI HQ
Lightle, Dani 24-OR277 24-BAR01 MARCONI HQ
Cochran, Kim 24-TX307 24-BAR01 MARCONI HQ

View Performance/Crop Safety Data

Field Research DirectorExpediteTrial DelayField ID#RFCTO QAHQ RECD.Lab ID#Lab RECDLab CompProc. IDProc. ShippedProc. ReportRaw DataS Dir./Auditor
Hu, Alex P 24-AZP04 -NONE PATEL
Wang, Yu-Chen P 24-CAP19 -NONE PATEL
Higgins, Doug P 24-VAP04 -NONE PATEL
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